This church stands on the site of an early Christian cemetery. According to tradition, the widow Serena buried St Sabinus here after his martyrdom in 303. The sarcophagus (late 4th century) of Lucius Baebius Sabinus, which was found here, is now in the Museo del Ducato di Spoleto (1.3).
There seems to have been a church dedicated to St Sabinus here from at least the late 6th century. Paul the Deacon made two references to it in his "History of the Lombards":
✴In 591, when Ariulf, Duke of Spoleto went into " the church of the blessed martyr, the bishop Sabinus, in which his venerable body reposes" because he had been told that Christian soldiers "were wont to invoke [St Sabinus] to their aid as often as they went to war". He recognised an image of St Sabinus as a portrait of a man who had protected him during his battle against the Byzantines at Camerino in 598. (Book 4, chapter 16).
✴The Lombard King Aribert II (701 - 12) exiled Peter (Petros), a relative of the future King Liutprand to Spoleto. As Peter prayed in "the church of the blessed martyr Sabinus", the saint appeared to him and told him that he would become Bishop of Pavia. When Liutprand came to the throne in 712, Peter duly became Bishop of Pavia and built a church dedicated to St Sabinus on his own property in the diocese.
In ca. 970, a representative of Bishop Theoderic I of Metz acquired St Serena's remains from San Sabino, along with other relics that were documented, perhaps incorrectly, as those of St Gregory. Theoderic took them back to Metz.
The present church on the site dates to the 12th century but it was re-modeled in Baroque style in 1623 and largely rebuilt after the earthquake of 1768.
During excavations in 2006, tombs from the Roman and Lombard periods were discovered.
Interior
The church has a nave and two aisles, with a raised presbytery over the crypt.
Madonna and Child with Saints [date??]
Martyrdom of St Sabinus [date??]
St Sabinus [date??]
Madonna della Misercordia [date??]
St Sabinus [date??]
Crypt