This church and the adjacent hospice for pilgrims stand on the Via Spina, which was an old pilgrim route from Rome to Compostella.
The earliest record of the complex dates to 1291, when the church became a parish church and the hospice was put under the control of the nuns of Santa Maria della Stella.
The church was re-modelled in the 16th century.
Interior
Frescoes in the apse (1526)
Surviving documents record that some thirty inhabitants of San Giacomo contributed towards the payment for these frescoes by Giovanni di Pietro, lo Spagna, which are dated by inscription.
✴The scenes to each side depict two episodes in a legend of a couple that was making a pilgrimage to Compostela with their young son. He was unjustly accused of theft and condemned to hang, after which they continued sadly on their way.
[These two scenes are also depicted in frescoes by Mezzastris in the Oratorio dei Pelligrini and in the stained glass (1511) designed by Mariotto di Nardo at San Domenico, Perugia.]
✴The frescoes on the triumphal arch depict:
•the figures of the Annunciation in tondi (above);
•St Lucy (on the left); and
•St Apollonia (on the right).
Madonna and Child with saints (1527)
Madonna and Child with saints (1530)
Madonna del Rosario (ca. 1570)
This fresco [where] was documented in 1625 as the work of “Henrico Fiamengo”, who was almost certainly the Flemish artist usually known in Italy as Arrigo Fiammingo. It depicts the Madonna and Child in glory, with SS Dominic and Francis below. The Madonna hands a rosary to St Dominic, who is surrounded by male members of a confraternity, presumably the Confraternita del Rosario. St Francis is surrounded by a group of ladies, who were presumably their female relatives. St Dominic holds a model of a domed church.