This was the site of an ancient hospice that belonged to the hermits of Monteluco. A number of Augustinian nuns moved here from Santa Maria della Stella in 1519 because they did not want to join the Lateran Congregation of the Augustinian Canonesses (a change made at Santa Maria della Stella in 1502).
In 1556, Bishop Alessandro Farnese gave them part of the responsibility for the administration of the hospice of Santa Croce (later San Carlo Borromeo), an obligation they retained until 1716.
The complex passed to the Congregazione delle Suore Oblate del Bambino Gesù in 1834. (This order was founded in Rome in 1671 and had its first nunnery outside Rome in Spoleto [where ??] from 1683).