Paolo Orsini di Narni and Bishop Pierdonato Cesi invited Sister Eusebia Borghese to establish a convent of Poor Clares here that was dedicated to the Roman martyr, St Restituta. 

The convent ran into financial difficulties in the 16th century, but recovered in 1610, when Paolo Emilio Cesi, Marquis of Riano left a substantial bequest to the community at the behest of Bishop Giambattista Tosca.  This money was used (inter alia) for a new high altar.

The few remaining nuns from Santa Margherita moved here in the 19th century, when their nunnery was suppressed.

Interior

Visitation (early 17th century)

Birth of St John the Baptist (ca. 1695)

The restoration, which could not completely remedy the damage sustained by the altarpiece, confirmed its traditional attribution to Antonio Gherardi.  It seems to belong to the later period of his career, when he also worked in Gubbio.