Giovanni Francesco Perini was born in Amelia.  He was documented in Rome in 1523, when Pope Hadrian VI absolved him from an act of homicide.  It is clear from this document that he had belonged to the team at work in the Vatican Palace both before and immediately after the death of Raphael (in 1520). 

Perini seems subsequently to have returned to Amelia, where he held political office on two occasions.  Two sons, Giulio and Bartolomeo worked with him.

Only one of his five documented works survives - see Amelia below.  The four lost works were:

1. ✴works (1525) in the Palazzo degli Anziani, Amelia;
   

2. ✴a panel (1528) of the Madonna and Child with SS Roch and Sebastian, [where?]; and
   

3. ✴two works (1538) in the village of Vitorchiano in Lazio, where he also had a home.
   

Amelia

Last Supper (1538)

Narni

Frescoes in San Domenico (16th century)

The frescoes which were painted in the right apsidal chapel of San Domenico have been recently attributed to Giovanni Francesco Perini:

1. 

   ✴Those on the right wall, which are still in situ, albeit that they are badly damaged, depict:
   

2. •SS Augustine and Ambrose, in the lunettes, and
   

3. •the Resurrection below.
   

Those on the left wall depicted:

1. 

   •SS Jerome and Gregory the Great, in the lunettes above, of which only the latter survives in situ; and
   

1. •the Last Supper.
   

2. 

   The detached fresco of St Jerome and the left part of the Last Supper below it are now in the Pinacoteca
   

1. ✴The frescoes on the back wall, which have been completely lost, presumably included a scene of the Crucifixion.